Memory is a key capability of LLM agents. Persistent memory extends this across sessions---enabling recall, revision, and personalization.

Yet its multi-stage pipeline (ingestion, retrieval, filtering, generation) makes failures difficult to localize: end-to-end evaluation reveals that an error occurred, but not which stage caused it. Existing evaluations often report aggregate performance without paired statistical comparisons, slice-level non-regression checks, or stage-level diagnostic traces.

We propose D$^2$ACCI (Diagnostic-Driven Artifact-based Closed-loop Controlled Iteration), a dual-loop protocol whose outer diagnostic gate promotes, feature-flags, or rejects memory interventions based on paired evidence, protected-slice monitoring, and trace-level localizability. We further introduce DCR, a graded observability metric that measures whether failures remain localizable, and D$^2$ACCI-Eval, a reusable artifact for gate replay.

We instantiate the protocol in MemStack and evaluate on three public benchmarks, achieving 93.59% on LoCoMo, 90.93% on LongMemEval, and 57.20% on PersonaMem-V2. Five paired ablations show that supplement extraction, session-memory retrieval, and Forget Guard yield statistically significant gains (+1.9 to +3.7pp, all p $\le$ .003).

In contrast, BM25/RRF is retained as a monitored feature flag---a distinction invisible to aggregate-only evaluation. A diagnostic audit shows enriched traces substantially improve root-cause agreement over result-only relabeling.

Diagnostic artifacts reach 98--100% DCR@3 versus 0% for results-only logs. These results establish that robust memory-system iteration demands traceable, statistically grounded, and regression-aware evidence---exactly the gap D$^2$ACCI fills.