Zero-shot anomaly detection aims to localize anomalies without target-domain samples. Existing CLIP-based methods suffer from coarse anomaly maps and limited semantic prompts.

We propose PSMP-CLIP, integrating patch-prompt SAM2 segmentation (PPSS) and multi-semantic guided prompt regularization (MSGPR). PPSS samples prompts directly from intermediate patch features, avoiding threshold drift and guiding SAM2 to produce precise masks.

MSGPR uses multiple learnable prompts constrained by semantic anchors to preserve generalization. Experiments on 14 datasets show highly competitive performance, achieving the best pixel-level AUROC on MVTec AD, BTAD, DTD-Synthetic, CVC-ClinicDB, TN3K, Endo, and Kvasir.